February 19, 2007 - Establishment of Las Piñas Science High School throuh R.A. 9451
June 8, 2009 - Opening of Classes. The first 24 students were temporarily housed at Las Pinas East National High School - Talon Village Annex.
July 30, 2009 - Inauguration of the Las Pinas Science High School Building at Carnival Park St., B.F. Resort Village, Talon Dos, Las Pinas City, Metro Manila.